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KMID : 0043320100330121891
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Archives of Pharmacal Research
2010 Volume.33 No. 12 p.1891 ~ p.1900
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Synthesis and antimicrobial activity of novel 5-amino-4-cyano-1H-pyrazole and quinazolin-4(3H)-one derivatives
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Abdel Aal Mohamed T.
Abdel Aleem Abdel Aleem H.
Ibahim Laila I.
Zein Ahmed L.
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Abstract
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New substituted aroylhydrazones (4a-f) were synthesized from the acid hydrazide (3) and the corresponding aldehyde or aldose. 5-Amino-4-cyano-1H-pyrazole derivatives (6a-f) were prepared by the reaction of the aroylhydrazones (4a-f) with malononitrile. The synthesized compounds were tested for antimicrobial activity against various bacteria and fungi and showed moderate to high inhibition activities. Compounds incorporating a sugar moiety as well as a pyrazolyl ring in their structure displayed the highest antimicrobial activity.
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KEYWORD
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Aroylhydrazones, 5-Amino-4-cyanopyrazole, Quinazoline-4-one, Antimicrobial activity
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